Endocrine Abstracts

Background and aim: Adipose and muscle tissue dysfunction are associated with obesity-related complications, especially insulin resistance (IR) and inflammation, which improve after weight loss. The underlying mechanisms are however not yet fully understood. This study investigates changes in systemic and regional markers of IR and inflammation during weight loss in subjects with obesity.Materials and methods: Twenty subjects with obesity (age 49±10...

Background: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p class="abs...

BackgroundPrecise diagnostics for postprandial reactive hypoglycaemic syndrome (PRHS) after gastric bypass surgery (GBS) are lacking. Oral glucose tolerance tests are advocated but might cause early dumping in this population and often cause hypoglycaemic values in a normal population.AimTo evaluate glycaemic responses during liquid and solid mixed meal tolerance tests (LMMTT and SMMTT) in a post-GBS populati...

Background: Men with obesity often have low total and, with increasing adiposity, also free testosterone (T) levels, which can partially restore when they lose weight. Although this is in part explained by lower sex-hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not fully unraveled whether changes in androgen metabolization contribute to this phenomenon.Aim: Investigating metabolisation of sex steroids d...